PCBs Polychlorinated biphenyls

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5. What are the effects of PCBs on laboratory animals?

• 5.1 At what exposure levels do PCBs cause harmful effects?
• 5.2 What are the effects of PCBs on reproduction?
• 5.3 What other biological effects can PCBs have?
• 5.4 Through what mechanisms do PCBs act?

The Level 3 "Source" text of this Digest is:

IPCS - WHO Polychlorinated biphenyls : Human health aspects. Concise international chemical assessment document 55 (2003)

It can be viewed at:

www.inchem.org/documents/cicads/cicads/cicad55.htm

or purchased as a printed book at the WHO bookshop.

5.1 At what exposure levels do PCBs cause harmful effects?

For more information on this question, see:

Section 8.1, Single exposure  ,
Section 8.2, Short-term exposure   and
Section 8.3, Long-term exposure and carcinogenicity  of the
IPCS - WHO Polychlorinated biphenyls : Human health aspects. Concise international chemical assessment document 55 (2003)

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5.2 What are the effects of PCBs on reproduction?

For more information on this question, see:

Section 8.5.1, Effects on fertility  ,
Section 8.5.2, Estrogen-related effects   and
Section 8.5.3, Developmental effects  of the
IPCS - WHO Polychlorinated biphenyls : Human health aspects. Concise international chemical assessment document 55 (2003)

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5.3 What other biological effects can PCBs have?

For more information on this question, see:

Section 8.4, Genotoxicity and related end-points  ,
Section 8.6, Immunotoxicity   and
Section 8.7, Neurochemical effects  of the
IPCS - WHO Polychlorinated biphenyls : Human health aspects. Concise international chemical assessment document 55 (2003)

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5.4 Through what mechanisms do PCBs act?

For more information on this question, see:

Section 8.8, Mode of action  of the
IPCS - WHO Polychlorinated biphenyls : Human health aspects. Concise international chemical assessment document 55 (2003)