Table 4: Short-term effects of ozone on lung function, biological and other responses

Reference Population Exposure Results
Broeckaert et al 2000
Cyclists In quartiles mean
48,72, 89 and 96
Significant elevations in CC-16 protein measured in Clara cells for those exposed to 3rd and 4th quartile
Holz et al
2002 (224)
Allergic asthmatics   Enhanced functional and inflamatory bronchial response to inhaled allergen challenge
Frampton et al 1995
Healthy and allergic asthmatic nonsmokers 3 hours to 80, 120 and 160 ppb after exposure to H2SO4 and NaCl Small, significant reductions in FVC, FEV in the highest exposure group, greater for those exposed to H2SO4 and bigger for asthmatics
Frank et al
2001 (223)
Young adults 0.25 ppm for 2h over 4 days Spirometric values show adaptation, persistent small airway dysfunction/resistance
Devlin et al
1997 (215)
Young male adults Repetitive exposures 0.4ppm for 2h over 5 days Inflammatory mediators are attenuated, some do not return to normal after 20 days upon O3 challenge. Several markers of cell injury are not attenuated

Source: WHO Regional Office for Europe  "Health Aspects of Air Pollution" (2003) Chapter 6, Ozone (O3) Section 6.2 Answer and rationales, Question 12

(For numbered references see pages 58-88)

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Table 2. Summary of meta-analysis of time-series studies published during the period 1996–2001

Table 3: Summary of studies measuring short-term effect on lung function

Table 4: Short-term effects of ozone on lung function, biological and other responses

Fig. 1: Funnel plot of black smoke and "daily all cause mortality" in 47 studies.

Table 1. Summary estimates for studies of PM10 and daily mortality by GAM or non-GAM statistical model and by single-city or multicity study design.