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3. Fate in the human body of DBP, DEHP, DINP and DIDP

Length of chain C4-C8 phthalates C9-C10 phthalates
  DBP
Dibutyl-phthalate
DEHP
Diethylexyl-phthalate
DINP
Diisononyl-phthalate
DIDP
Di-isodecyl-phthalate
3.1.Absorption into the bloodstream Almost complete absorption (90%) via the oral route.
Absorption via the dermal route is high in rats but is much lower in humans.
Absorption via the respiratory route by inhalation possible (vapour or aerosol).
Readily (about 50%) absorbed via the oral route.
Absorption via the dermal route is very low in rats.
Absorption via the respiratory route when administered as an aerosol.
Readily (about 50%) absorbed via the oral route.
Absorption via the dermal route is very low in rats and even lower in humans.
Absorption via the respiratory route when administered as an aerosol.
Readily (about 50%) absorbed via the oral route.
Absorption via the dermal route is very low in rats and even lower in humans.
Absorption via the respiratory route when administered as an aerosol.
3.2.Tissue distribution The parent compound and its metabolites do not accumulate in tissues.
They can penetrate the placenta but don’t accumulate in embryonic or fetal tissues.

The parent compound and its metabolites do not accumulate in tissues. The parent compound and its metabolites do not accumulate in tissues. The parent compound and its metabolites do not accumulate in tissues.
3.3.Metabolism Degradation by hydrolysis occurs in the gastrointestinal tract before absorption. The main hydrolysis products are the monoester (MBP) and butyl alcohol.
After absorption, the parent compound and MBP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
Degradation by hydrolysis occurs in the gastrointestinal tract before absorption. The main hydrolysis products are the monoester (MEHP) and 2-ethyl hexanol.
After absorption, the parent compound and MEHP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
Degradation by hydrolysis occurs in the gastrointestinal tract before absorption. The main hydrolysis products are the monoester (MINP) and isononyl alcohol.
After absorption, the parent compound and MINP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
Degradation by hydrolysis occurs in the gastrointestinal tract before absorption. The main hydrolysis products are the monoester (MIDP) and isodecyl alcohol.
After absorption, the parent compound and MIDP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
3.4.Excretion The major route of excretion of the parent compound and its metabolites is the urine. There is also excretion via the bile.
The metabolites excreted in the intestinal tract via the bile are reabsorbed (entero-hepatic circulation).
The major routes of excretion of the parent compound and its metabolites are the urine and the feces.
The metabolites are rapidly excreted in the urine as oxidation products of MEHP and phthalic acid. There is also excretion via the bile.
The parent compound has been shown to be excreted in the milk of lactating rats and women.
The major routes of excretion of the parent compound and its metabolites are the urine and the feces.
The metabolites are rapidly excreted in the urine as oxidation products of MINP and phthalic acid.
The major routes of excretion of the parent compound and its metabolites are the urine and the feces. - The metabolites are rapidly excreted in the urine as oxidation products MIDP and phthalic acid.
The parent compound has been shown to be excreted in the milk of lactating rats.
Related publications:
DBP home DBP DEHP home DEHP DIDP-DINP home DIDP-DINP
Other Tables in this publication:

Table 1. Regulatory classifications of DBP, DEHP, DINP and DIDP

Table 2. Conclusions on the risk assessments of DNBP, DEHP, DINP and DIDP

Table 3. Fate of the phthalates in the human body

Table 4. Potential adverse effects of DBP, DEHP, DINP and DIDP

Table 5. Potential environmental effects of DBP, DEHP, DINP and DIDP

Table 6. Key physico-chemical properties of DBP, DEHP, DINP and DIDP