3.1.Absorption into the bloodstream
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Almost complete absorption (90%) via the oral route. Absorption via the dermal route is high in rats but is much lower in humans. Absorption via the respiratory route by inhalation possible (vapour or aerosol).
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Readily (about 50%) absorbed via the oral route. Absorption via the dermal route is very low in rats. Absorption via the respiratory route when
administered as an aerosol.
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Readily (about 50%) absorbed via the oral route. Absorption via the dermal route is very low in rats
and even lower in humans. Absorption via the respiratory route when
administered as an aerosol.
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Readily (about 50%) absorbed via the oral route. Absorption via the dermal route is very low in rats and even lower in humans. Absorption via the respiratory route when administered as an aerosol.
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3.2.Tissue distribution
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The parent compound and its metabolites do
not accumulate in tissues.They can penetrate the placenta but don’t
accumulate in embryonic or fetal tissues.
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The parent compound and its metabolites do not
accumulate in tissues.
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The parent compound and its metabolites do not
accumulate in tissues.
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The parent compound and its metabolites do not
accumulate in tissues.
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3.3.Metabolism
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Degradation by hydrolysis occurs in the
gastrointestinal tract before absorption. The main hydrolysis products are
the monoester (MBP) and butyl alcohol. After absorption, the parent compound and MBP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
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Degradation by hydrolysis occurs in the
gastrointestinal tract before absorption. The main hydrolysis products are
the monoester (MEHP) and 2-ethyl hexanol. After absorption, the parent compound and MEHP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
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Degradation by hydrolysis occurs in the gastrointestinal tract before absorption. The main hydrolysis products are the monoester (MINP) and isononyl alcohol. After absorption, the parent compound and MINP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
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Degradation by hydrolysis occurs in the
gastrointestinal tract before absorption. The main hydrolysis products are
the monoester (MIDP) and isodecyl alcohol.After absorption, the parent compound and MIDP are further metabolized by hydrolysis and oxidation in the liver and the kidneys.
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3.4.Excretion
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The major route of excretion of the parent compound and its metabolites is the urine. There is also excretion via the bile.The metabolites excreted in the intestinal tract via the bile are reabsorbed (entero-hepatic circulation).
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The major routes of excretion of the parent compound and its metabolites are the urine and the feces. The metabolites are rapidly excreted in the urine as oxidation products of MEHP and phthalic acid. There is also excretion via the bile.The parent compound has been shown to be excreted in
the milk of lactating rats and women.
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The major routes of excretion of the parent compound and its metabolites are the urine and the feces. The metabolites are rapidly excreted in the urine as
oxidation products of MINP and phthalic acid.
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The major routes of excretion of the parent compound and its metabolites are the urine and the feces. - The metabolites are rapidly excreted in the urine as oxidation products MIDP and phthalic acid.The parent compound has been shown to be excreted in the milk of lactating rats.
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