Similar term(s): biological endpoint.
A biological endpoint is a direct marker of disease progression - e.g. disease
symptoms or death - used to describe a health effect (or a probability of that
health effect) resulting from exposure to a chemical.
Exposure to a particular chemical may lead to a series of endpoints. The most
sensitive endpoint (critical endpoint) is the one that occurs at the lowest
The derivation of a tolerable daily intake
(TDI) or an acceptable daily intake
(ADI) is based on the
NOAEL (no observed adverse effect level) of
the most sensitive endpoint and will also ensure protection against all other
Acceptable Daily Intake - NOAEL - Tolerable Daily Intake