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Hazards and risk associated to Perfluorooctanoic acid (PFOA), its salts and PFOA-related substances

 

Glossary over Hazards and risk associated to Perfluorooctanoic acid (PFOA), its salts and PFOA-related substances

Absorption

The process of taking in. For a person or an animal, absorption is the process of a substance getting into the body through the eyes, skin, stomach, intestines, or lungs. (Source: ATSDR Glossary of Terms  )

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Acute

Occurring over a short time [compare with chronic]. (Source: ATSDR Glossary of Terms  )

Adverse health effect

A change in body function or cell structure that might lead to disease or health problems. (Source: ATSDR Glossary of Terms  )

American Cancer Society

"The American Cancer Society (ACS) is a nationwide, community- based voluntary health organization. Headquartered in Atlanta, Georgia, the ACS has state divisions and more than 3,400 local offices."

"The American Cancer Society is the nationwide community- based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives, and diminishing suffering from cancer, through research, education, advocacy, and service."

"The American Cancer Society's international mission concentrates on capacity building in developing cancer societies and on collaboration with other cancer-related organizations throughout the world in carrying out shared strategic directions." (Source: ACS website  )

Antibody

A protein produced by the body's immune system that recognizes and helps fight infections and other foreign substances in the body. (Source: Gift of a Lifetime Glossary  )

Atmosphere

The mass of air surrounding the Earth.

The atmosphere consists of nitrogen (78%), oxygen (21%), and traces of other gases such as argon, helium, carbon dioxide, and ozone.

The atmosphere plays an important role in the protection of life on Earth; it absorbs ultraviolet solar radiation and reduces temperature extremes between day and night. (Source: GreenFacts)

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Atom

The smallest particle of an element that still conserves the chemical properties of that element. Atoms are composed of electrons, protons, and neutrons. (Source: GreenFacts)

Bacterial resistance

Bacterial resistance is the capacity of bacteria to withstand the effects of antibiotics or biocides that are intended to kill or control them. (Source: GreenFacts, based on the  SCENIHR opinion on Antibiotic Resistance Effects of Biocides )

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Bioaccumulation

Bioaccumulation is used to describe the increase in concentration of a substance in an organism over time.

Bioaccumulative substances tend to be fat soluble and not to be broken down by the organism. (Source: GreenFacts )

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Biologic uptake

The transfer of substances from the environment to plants, animals, and humans. (Source: ATSDR Glossary of Terms )

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Biomagnification

The term biomagnification refers to the progressive build up of persistent substances by successive trophic levels - meaning that it relates to the concentration ratio in a tissue of a predator organism as compared to that in its prey. (Source: GreenFacts)

Blood serum

Clear, watery fluid of the blood that separates when blood clots. (Source: GreenFacts)

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Cancer

Any one of a group of diseases that occur when cells in the body become abnormal and have the potential to spread and establish growth in nearby tissues and other parts of the body (malignancy). (Source: GreenFacts )

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Carcinogen

A substance, factor or situation that causes or induces cancer. (Source: GreenFacts )

Chemical element

A substance which cannot be separated into its constituent parts and still retains its chemical identity. For example, sodium (Na) is an element. (Source: US EPA Drinking Water Glossary  )

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Cholesterol

A fat-like substance that is found in certain foods and is also produced in the body.

Cholesterol travels through the bloodstream in different packages called lipoproteins. Low-density lipoproteins (LDL or "bad" cholesterol) deliver cholesterol to the body, while high-density lipoproteins (HDL or "good" cholesterol) take cholesterol out of the bloodstream. (Source: PBS Glossary of Medical Terms  )

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Compound(s)

A material made up of two or more elements combined in a fixed ratio. (Source: CoRIS glossary  )

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Concentration

The amount of a chemical or substance present in a particular quantity of soil, water, air, food, blood, hair, urine, breath, or any other media. (Source: GreenFacts)

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Contaminant(s)

A substance that is either present in an environment where it does not belong or is present at levels that might cause harmful effects to humans or the environment. (Source: GreenFacts)

Degradation of ecosystems

A persistent reduction in the capacity to provide ecosystem services. (Source: MA  Glossary )

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Developmental effects

Effects in the developing offspring due to exposure before conception (either parent), prenatally, or postnatally to the time of sexual maturation. Developmental effects may be expressed at any time in the life span of the organism. Developmental effects are a subset of reproductive effects. (Source: CSIRO CSIRO biological effects and safety of EMR Glossary  )

Endpoint

A biological endpoint is a direct marker of disease progression - e.g. disease symptoms or death - used to describe a health effect (or a probability of that health effect) resulting from exposure to a chemical. (Source: GreenFacts)

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Epidemiology

The study of the patterns, causes, and control of disease in groups of people. (Source: NCI NCI cancer.gov dictionary  )

European Chemicals Agency

"ECHA is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and addresses chemicals of concern." (Source: https://echa.europa.eu/home   )

Exposure

Contact of the cells of an organism with a substance, micro-organism or radiation. In the case of humans, this may involve contact with a substance or agent by swallowing, breathing, or through the skin or eyes. Exposure may be short-term [acute exposure], of intermediate duration, or long-term [chronic exposure].

Exposure can be divided into external and internal.

External exposure refers to the whole dose to which an organism is exposed.

Internal exposure refers only to that fraction of the initial chemical dose that is absorbed and distributed throughout the body via systemic circulation. (Source: GreenFacts)

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Foetus

The embryo is referred to as a foetus after it has reached a certain stage of organ development (in humans this is eight weeks after conception). (Source: CSIRO Glossary of terms  )

Food web

The interconnected food chains (feeding relationships) in an ecosystem. Plants, herbivores, and carnivores all form parts of the food web. (Source: GreenFacts)

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Gene expression

The process by which a gene is "turned on" to produce the specific biological molecule encoded by that gene (usually protein or RNA). (Source: GreenFacts )

Genes

The functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. (Source: NHGRI Talking Glossary of Genetic Terms  )

Global scale

The geographical realm encompassing all of Earth. (Source: MA  Glossary )

Half life

The term which is used for the time required for the amount of a particular substance to be reduced to one half of its value when the rate of decay is exponential.

Radioactive half-life refers to the decay of radioactive substances. Iodine-131, for instance, has a half-life of 8 days whereas that of Plutonium-239 is more than 23 000 years.

Biological half-life refers to decay by biological processes. Substances with a long biological half-life will tend to accumulate in the body and are, therefore, particularly to be avoided. Substances with a short biological half-life may accumulate if some becomes tightly bound, even if most is cleared from the body rapidly. There is also the possibility of cumulative effects of chemicals which have a short residence time in the body. (Source: GreenFacts)

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Hormone(s)

Chemical messengers that help our body do different tasks. Hormones are produced by the endocrine glands and then sent all over the body to stimulate certain activities. For example, insulin is a well-known hormone that helps our body digest food. Hormones regulate our growth, digestion, reproduction and sexual function. (Source: EMCOM Endocrine disruptors glossary  )

Human health

A state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.

The health of a whole community or population is reflected in measurements of disease incidence and prevalence, age-specific death rates, and life expectancy. (Source: MA Glossary  )

Mammary glands

The milk-producing glands of female mammals. These glands typically begin secreting milk when young are born.

Rudimentary mammary glands are generally also found in males, but they cease development well before puberty. (Source: GreenFacts)

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Market-based instruments

Instruments of environmental policies in which a change in technology, behaviour or products is encouraged through financial incentives (either subsidies, taxes, price differentiation or market creation). (Source: Environmental Programme for the Danube River Basin Glossary   )

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Metabolism

The conversion or breakdown of a substance from one form to another by an enzyme. (Source: GreenFacts, based on ATSDR Glossary of Terms )

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Model

Mathematical representation or simulation of an actual situation. (Source: GreenFacts)

Molecule

A molecule is the smallest part of any chemical compound composed of two or more atoms and which has the qualities of that substance and can exist alone in a free state. As an example, a molecule of water (H2O) consists of two atoms of hydrogen and one of oxygen. (Source: GreenFacts, based on Helios Glossary   )

Persistent organic pollutants

Persistent organic pollutants (POPs) are chemical substances that persist in the environment, bioaccumulate through the food web, and pose a risk of causing adverse effects to human health and the environment. This group of priority pollutants consists of pesticides (such as DDT), industrial chemicals (such as polychlorinated biphenyls, PCBs) and unintentional by-products of industrial processes (such as dioxins and furans).

Persistent Organic Pollutants are transported across international boundaries far from their sources, even to regions where they have never been used or produced. (Source: European Commission Environment DG POPs  )

pH

pH is a measure of the concentration of protons (H+) in a solution and, therefore, its acidity or alkalinity. The concept was introduced by S.P.L. Sørensen in 1909. The p stands for the German "Potenz", meaning power or concentration, and the H for the hydrogen ion (H+). In layman's terms , the "pH" value is an approximate number between 0 and 14 that indicates whether a solution is acidic (pH < 7), basic (pH > 7) or neither (pH = 7) [neutral]. (Source: GreenFacts )

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Polymer

A polymer is a high-molecular-weight organic compound, natural or man-made, consisting of many repeating simpler chemical units or molecules called monomers.

Examples of natural polymers are proteins (polymer of amino acids) and cellulose (polymer of sugar molecules).

An example of synthetic polymer is PVC (a polymer of vinyl chloride). (Source: GreenFacts)

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Population

A group or number of people living within a specified area or sharing similar characteristics (such as occupation or age). (Source: ATSDR Glossary of Terms  )

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Precursor(s)

A precursor is a chemical which precedes and is the source of another. (Source: GreenFacts)

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Predicted Environmental Concentration

The Predicted Environmental Concentration is an indication of the expected concentration of a material in the environment, taking into account the amount initially present (or added to) the environment, its distribution, and the probable methods and rates of environmental degradation and removal, either forced or natural. (Source: The Physical and Theoretical Chemistry Laboratory Chemical Safety Information - Glossary )

Predicted No Effect Concentration

The predicted no-effect concentration (PNEC) is the concentration below which exposure to a substance is not expected to cause adverse effects. (Source: GreenFacts)

Primary & secondary particles

Primary particles are directly released into the atmosphere by wind, combustion processes, or human activities.

Secondary particles are those that form in the atmosphere from other gaseous pollutants, particularly sulfur dioxide, nitrogen oxides, ammonia, and volatile organic compounds. (Source: GreenFacts)

Production / Productivity

Production is the process of creating, growing, manufacturing, or improving goods and services. It also refers to the quantity produced.

In economics, productivity is used to measure the efficiency or rate of production. It is the amount of output (e.g. number of goods produced) per unit of input (e.g. labor, equipment, and capital).

In biology, productivity is a measure of the efficiency with which a biological system converts energy into growth. (Source: GreenFacts)

Reduction (in fish processing)

Transformation of fish into fish meal and oil. (Source: FAO Fisheries Glossary  )

Risk

The probability that something will cause injury or harm. (Source: ATSDR Glossary of Terms  )

Risk assessment

A scientifically based process consisting of four steps:

  • hazard identification,
  • hazard characterization,
  • exposure assessment and
  • risk characterization
(Source:   Official Journal of the European Communities 2002 L 31 )

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Risk management

The process, distinct from risk assessment, of weighing policy alternatives in consultation with interested parties, considering risk assessment and other legitimate factors, and, if need be, selecting appropriate prevention and control measure. (Source: Official Journal of the European Communities 2002 L 31   )

Sealant

Any substance that is used to fill or close small gaps and cracks in another material. (Source: GreenFacts )

Sewage

Sewage refers to waste-water from homes and industry which is collected and carried away in sewers (pipes or tunnels). When raw waste-water is cleaned in treatment plants the waste product is sewage sludge, which can be used as a fertiliser under certain conditions or deposited in landfills. (Source: GreenFacts )

Species

A group of organisms that differ from all other groups of organisms and that are capable of breeding and producing fertile offspring. This is the smallest unit of classification for plants and animals. (Source: OceanLink Glossary of Common Terms and Definitions in Marine Biology  )

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Stockholm Convention

The Stockholm Convention on Persistent Organic Pollutants is a global treaty to protect human health and the environment from chemicals that remain intact in the environment for long periods, become widely distributed geographically, accumulate in the fatty tissue of humans and wildlife, and have harmful impacts on human health or on the environment. Exposure to Persistent Organic Pollutants (POPs) can lead to serious health effects including certain cancers, birth defects, dysfunctional immune and reproductive systems, greater susceptibility to disease and damages to the central and peripheral nervous systems. Given their long range transport, no one government acting alone can protect its citizens or its environment from POPs.

In response to this global problem, the Stockholm Convention, which was adopted in 2001 and entered into force in 2004, requires its parties to take measures to eliminate or reduce the release of POPs into the environment. (Source: Website   )

Surfactant

A surfactant is a substance that reduces the surface tension of a liquid in which it is dissolved.

When dissolved in water a surfactant gives a product the ability to remove dirt from surfaces such as the human skin, textiles, and other solids. (Source: GreenFacts)

The European Monitoring Centre for Drugs and Drug Addiction

The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) was established in 1993.

Inaugurated in Lisbon in 1995, it is one of the EU’s decentralised agencies.

The EMCDDA exists to provide the EU and its Member States with a factual overview of European drug problems and a solid evidence base to support the drugs debate.

Today it offers policymakers the data they need for drawing up informed drug laws and strategies. It also helps professionals and practitioners working in the field pinpoint best practice and new areas of research. (Source: www.emcdda.europa.eu   )

The International Renewable Energy Agency

The International Renewable Energy Agency (IRENA) is an intergovernmental organisation that supports countries in their transition to a sustainable energy future, and serves as the principal platform for international cooperation, a centre of excellence, and a repository of policy, technology, resource and financial knowledge on renewable energy. IRENA promotes the widespread adoption and sustainable use of all forms of renewable energy, including bioenergy, geothermal, hydropower, ocean, solar and wind energy in the pursuit of sustainable development, energy access, energy security and low-carbon economic growth and prosperity. (Source: www.irena.org/  )

The Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection

The Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection (GESAMP) is an advisory body, established in 1969, that advises the United Nations (UN) system on the scientific aspects of marine environmental protection.

At present GESAMP is jointly sponsored by nine UN organizations with responsibilities relating to the marine environment, and they utilize GESAMP as a mechanism for coordination and collaboration among them. GESAMP functions are to conduct and support marine environmental assessments, to undertake in-depth studies, analyses, and reviews of specific topics, and to identify emerging issues regarding the state of the marine environment. GESAMP itself today consists of 16 experts, drawn from a wide range of relevant disciplines, who act in an independent and individual capacity. Studies and assessments are usually carried out by dedicated working groups, most of whose members are not sitting members of GESAMP but part of the broader GESAMP network.

GESAMP's UN sponsors: IMO, FAO, UNESCO-IOC, WMO, IAEA, UN, UNEP, UNIDO, UNDP.GESAMP

Source: (Source: www.gesamp.org/about  )

Threshold (in an ecosystem)

The level of magnitude of a system process at which sudden or rapid change occurs. (Source: PhysicalGeography.net Glossary of terms  )

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Thyroid gland

The thyroid gland consists of two bodies like small walnuts; they are connected by an isthmus beside the larynx (voice box). The thyroid gland produces thyroid hormones T3 and T4 which regulate the metabolism of all cells in the body. Disorders of the thyroid gland are characterized by the inability to produce or release sufficient thyroid hormones (hypothyroidism) or the overactivity of the thyroid gland (hyperthyroidism). (Source: EMCOM Endocrine Disruptors Glossary  )

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Toxic

Able to poison or harm an organism. Toxic substances can cause adverse health effects. (Source: GreenFacts)

Toxicity

The capacity or property of a substance to cause adverse effects. (Source: GreenFacts)

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Uncertainty

An expression of the degree to which a future condition (e.g., of an ecosystem) is unknown.

Uncertainty can result from lack of information or from disagreement about what is known or even knowable. It may have many types of sources, from quantifiable errors in the data to ambiguously defined terminology or uncertain projections of human behavior. Uncertainty can therefore be represented by quantitative measures (e.g., a range of values calculated by various models) or by qualitative statements (e.g., reflecting the judgment of a team of experts). (Source: Millennium Ecosystem Assessment  Glossary )

US Environment Protection Agency

The Environment Protection Agency's of the USA was founded in 1970. It's "mission is to protect human health and to safeguard the natural environment — air, water, and land — upon which life depends."

The EPA enforces federal environmental protection laws. It registers and regulates pesticides, enforces laws covering outdoor air and drinking water quality and regulates the disposal of hazardous and solid wastes.

It has now grown into a big and powerful administration: "18,000 people in Headquarters program offices, 10 regional offices, and 17 labs across the country, EPA employs a highly educated, technically trained staff, more than half of whom are engineers, scientists, and environmental protection specialists. A large number of employees are legal, public affairs, financial, and computer specialists."

U.S. EPA's scientific publications are widely recognized as reference materials. (Source: US EPA website  )


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